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How does ONTOZRY®▼ (cenobamate) work?

ONTOZRY®: A DUAL MECHANISM OF ACTION

ONTOZRY® is thought to prevent seizure initiation and reduce seizure propagation through its action on two elements of the neurological signalling pathways involved in epilepsy. The precise mechanism of action by which ONTOZRY® exercises its therapeutic effects in patients with focal-onset seizures is unknown.1-5

ONTOZRY® has a dual, complementary mechanism of action which is thought to contribute to its antiseizure activity and improved clinical efficacy in adult patients with focal onset epilepsy.6

  1. ONTOZRY® Summary of Product Characteristics.
  2. Löscher W, et al. Epilepsia. 2021 Mar;62(3):596-614.
  3. Schmidt D, Schachter SC. BMJ. 2014;348:g254.
  4. Nakamura M, et al. Eur J Pharmacol. 2019;855:175-82.
  5. Sharma R, et al. Eur J Pharmacol. 2020;879:173117.
  6. Guignet M, et al. Epilepsia. 2020 Nov;61(11):2329-2339.

 

UK14537P | November 2022